Welcome to the Bio-Sensing and Bio-Robotics laboratory webpage. We are in the Mechanical Engineering department at the University of Minnesota-Twin Cities. Our laboratory develops new technologies in the emerging frontier of in vivo robotic engineering- developing scalable, multi-modal, multi-dimensional robotic tools for cellular resolution interrogation of the intact brain. The research is at the intersection of robotics, precision engineering, in vivo neuroscience. Applications of such tools will range from basic scientific studies of the simple intact cellular networks, drug discovery, as well as enabling novel studies in the clinic.
- Matthew Rynes successfully defends his Masters Thesis. Matt worked along with Leila Ghanbari to apply principles of computer numerical controlled machining to microsurgical procedures.
- Our paper describing robotic multi-neuron patching in vivo is accepted for publication at Elife!
- Nahom Mossazghi gives a talk at the Annual Biomedical Research Conference for Minority Students (ABRCMS) in Phoenix, AZ
- Leila Ghanbari and Matthew Rynes present at the Annual Society for Neuroscience conference.
- Our paper describing computer vision guided robotic patch clamping in vivo is published in Neuron
- Paper describing engineered infrared fluorescent proteins for neuroimaging is published in Biophysics Journal
Our paper describing how realtime high resolution two-photon imaging can assist targeted patch clamp recordings of rare cell types in the brain is out in Neuron. Accompanying perspective article in The Scientist, and MIT News.
Lab undergraduate student, McNair Scholar, and MnDrive Fellow Nahom Mossazghi is selected to be a part of the National Institute of Health (NIH) Undergraduate Scholars Program. The program covers $20,000 in tuition expenses and a one year research traineeship at the NIH main campus in Bethesda Maryland after graduation!
Our breakthrough in non-invasive deep brain stimulation using temporally interfering high frequency electric fields is published in Cell! Collaboration led by Nir Grossman at University College London. Some perspective pieces in popular press: New York Times, Guardian, The Scientist, Science and IEEE spectrum
ME freshman Judith Dominguez receives Undergraduate Research Opportunities award for her proposed summer research work in the lab!
Our paper examining the role of mesoscale duration membrane fluctuation events and their role in gating neuronal spiking during behavior is published in J Neurophysiology! This is a collaboration with the Singer Lab at Georgia Tech and Boyden lab at MIT and demostrates the use of robotic patch clamping systems for
The lab receives a seed grant from MIT’s McGovern Institute Neurotechnology (MINT) fund, kickstarting a collaboration with Mark Harnett’s Lab at MIT. The collaboration aims to engineer a robotic platform for high density intracellular recordings from intact mammalian circuits in vivo.
Gabriella Shull joins the lab. Gabi is a NSF IGERT Neuroengineering trainee interested in engineering novel high density neural recording devices.
Leila Ghanbari wins the 2017 University of Minnesota Informatics Institute(UMII) Graduate Fellowship!
Nature news feature on our collaborative project developing a non-invasive transcranial deep brain stimulator, presented recently at the Society for Neuroscience conference. The effort is headed by Nir Grossman (University College London), Ed Boyden (MIT), Li- Huey Tsai (MIT) and Alvaro Pascual-Leone (Harvard).
The autopatcher has now gone fully autonomous! Ilya Kolb and colleagues at Georgia Tech in their recent Nature Scientific Reports paper, utilize an elegant pipette cleaning method to demonstrate the first system to perform sequential patch-clamp recordings without a human operator using a single pipette.
Suhasa gives a talk at the Max Planck Institute for Evolutionary Anthropology at Leipzig Germany.
We welcome new lab members: Gregory Johnson, Jay Hu, Lenora Haltom and Micheal Laroque.
We start moving into our permanent lab space in the newly renovated mechanical engineering building!
Our paper describing integration of microscopy and computer vision for image guided autopatching in brain slices has now been published as an innovative methodology in the Journal of Neurophysiology! Collaboration with the Chubykin lab at Purdue, Forest lab at Gatech, Boyden lab at MIT and Hongkui Zheng’s group at the Allen Institute for Brain Science.
Nature publishes a perspective article on state-of-the-art robotic tools being used for single neuron recordings in intact brains. Featuring our recently published Nature Protocols and the 2012 Nature Methods articles!
Our paper describing methodologies to setup and use the Autopatcher for in vivo single neuron electrophysiology was published in Nature Protocols! Want to set one up in your own lab? Check out www.autopatcher.org as well!
Its been 7 weeks since we got the lab space. Unveiling our fully functional setup!
Leila Ghanbari joins the lab as the first graduate student in the team!
Got our temporary lab space which we will be using until this Fall. First packages begin to stream in!
After a meandering road trip, Suhasa and family reached Minnesota on an unusually warm December morning (thanks El Nino). Immediately treated to that famed Minnesota accent at the first rest stop.